Impossible Now To Justify Drug Tests on Animals

Every now and then I write about animal testing and every time that I write about it, it becomes less and less justifiable and more are more unnecessary.  This is because, in part, science is developing methods to test drugs on artificial human organs which quite naturally does away with the need for experiments on animals.  I am putting aside for a minute the ethics of animal testing.  I know it is controversial but I am convinced that any decent person will see animal testing as unethical, inhumane, unjustifiable and untenable.

Animal testing on a cat

Recent news puts one more nail in the coffin of drug tests on animals because most of these tests are flawed and biased say analysts.
Researchers have discovered that more than 66% of experiments carried out on animals at leading universities contain flaws.  In addition, scientists engaged in animal testing may have been biased in their findings.  Further, it has been said that the effectiveness of some cancer drugs might have been overstated by almost 50%.  This is because the testing procedures upon which the conclusions were made were not conducted rigourously enough.

It is said that pharmaceutical companies often struggle to confirm in the real world the results of drug tests on animals which leads us to believe that the testing is inaccurate and therefore unjustified. It should be dawning upon pharmaceutical companies that the cost of inaccurate, biased and poorly conducted drug tests on animals is costing them billions.

Researchers at the University of Edinburgh analysed animal studies over 70 years. They found that in only a small fraction of the overall number of experiments the scientists had taken steps to avoid bias (“blinded” the researchers).  This lack of rigour was found to have taken place in drugs test on animals published in the most respected journals and coming from top universities such as Bristol and King’s College London.

One reason for the inaccuracy in drug testing in animals is that there is a need for biologists to publish positive results.  I suppose that they are driven to this goal by their employers: the large pharmaceutical companies.

An example of a flawed set of animal experiments are those carried out in the development of stroke treatments: NXY and tirilazad.  These drugs failed in clinical trials after showing positive results in animal experiments.

Another example of failed animal testing is in respect of sunitinib, a kidney cancer drug.  Testing was carried out on mice and the effect had been exaggerated by the scientists.

Jonathan Kimmelman of McGill University in Montréal said that the early stages of research work was:

“plagued by poor design and reporting practices, exposing patients to harmful and inactive agents, wasting time in the lab and driving up the price of drugs.”

The Chief Executive of the National Centre For the Replacement, Refinement and Reduction of Animals in Research said that it was time to stop wasting animals on inadequately robust experiments.

As mentioned, this article simply discusses the ineffectiveness of drug tests on animals. If we add to that the unethical aspect of animal drug testing we are forced to come to the conclusion that it is time to stop them and invest in more humane alternatives such as artificial organs designed specifically for testing procedures.

13 thoughts on “Impossible Now To Justify Drug Tests on Animals”

  1. Michael – I see you realized after your initial response (“read the article before commenting”) that my “oops” comment was made with tongue firmly planted in cheek. Sorry, I couldn’t resist. When I read the headline before I clicked the article, my first thought WAS that it concerned the testing of animals for drugs (antibiotics in cattle, etc.). I then read it.

    On a serious note, I too am against testing of drugs on animals on ethical grounds. However, the other reasons you list for not testing on animals – poorly designed tests, “cherry-picking” or falsifying test data, avoiding bias – are not unique to animal testing. I’m certain there are many other studies that show the same problems in all stages of drug testing, whether or not animals are involved -including final human testing.

    These problems will continue to plague all aspects of drug testing as long the financial stakes are so high. The unrelated, but instructive case of VW’s emission testing cheating illustrates what can happen to ethical constraints even in “respected” companies when profits are on the line.

    The drug companies’ logical response to your cited evidence would be to say “Yes, we agree, but that was in the past, and we have learned from those mistakes. We have now put protocols in place to ensure that all current and future testing is bias-free, well designed and carefully peer reviewed “.

    As to the ethical argument, their response has alway been that animal testing speeds drugs to the market, thus potentially saving human lives and in the process reducing the risk of serious complications in final human testing.

    I’m not buying either response. To the first, I’ll believe it when I see it. The drug companies have known about the testing protocol problems for years and we have yet to see clear evidence that they have been addressed. To the second (saving human lives), I say “show me the data”. They can’t.

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